Lipid-based delivery systems and intestinal lymphatic drug transport: A mechanistic update
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چکیده
منابع مشابه
Liposomal delivery systems for intestinal lymphatic drug transport
Intestinal lymphatic drug delivery has been widely studied because drugs can bypass the first-pass metabolism in the liver via the lymphatic route, which increases oral bioavailability. Various lipid-based nanoparticles have been used to deliver hydrophobic drugs to the lymphatic pathway. This review focuses on the liposomal delivery systems used for intestinal lymphatic drug transport. Liposom...
متن کاملLipid-Based Drug Delivery Systems
The principle objective of formulation of lipid-based drugs is to enhance their bioavailability. The use of lipids in drug delivery is no more a new trend now but is still the promising concept. Lipid-based drug delivery systems (LBDDS) are one of the emerging technologies designed to address challenges like the solubility and bioavailability of poorly water-soluble drugs. Lipid-based formulati...
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The delivery of drugs and bioactive compounds via the lymphatic system is complex and dependent on the physiological uniqueness of the system. The lymphatic route plays an important role in transporting extracellular fluid to maintain homeostasis and in transferring immune cells to injury sites, and is able to avoid first-pass metabolism, thus acting as a bypass route for compounds with lower b...
متن کاملThe lymph lipid precursor pool is a key determinant of intestinal lymphatic drug transport.
The influence of the size and turnover kinetics of the enterocyte-based lymph lipid precursor pool (LLPP) on intestinal lymphatic drug transport has been examined. Mesenteric lymph duct-cannulated rats were infused intraduodenally with low (2-5 mg/h) or high (20 mg/h) lipid-dose formulations containing 100 microg/h halofantrine (Hf, a model drug) and 1 microCi/h (14)C-oleic acid (OA) (as a mark...
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OF THE THESIS ....................................................................................... ii ACKNOWLEGEMENT.................................................................................................. iv TABLE OF CONTENTS ................................................................................................. v LIST OF TABLES ..............................................
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ژورنال
عنوان ژورنال: Advanced Drug Delivery Reviews
سال: 2008
ISSN: 0169-409X
DOI: 10.1016/j.addr.2007.09.007